Researchers discover weak link in Alzheimer’s drug candidates

Some current therapies being investigated for Alzheimer’s disease may cause further neural degeneration and cell death, according to a breakthrough discovery by UC San Diego researchers.

By combining three dimensional computer simulations with high resolutionatomic force microscopy membrane protein and cell imaging, electrical recording and various cellular assays, UCSD nano-biophysicist Ratnesh Lal and his colleagues investigated the structure and function of truncated peptides, known as nonamyloidgenic peptides, formed by some Alzheimer’s drug candidates. The researchers found that the nonamyloidgenic peptides formed active ion channels that caused the cells to take in very high levels ofcalcium ions, which damaged synaptic efficiency and eventually killed neurons, neurons that are linked to memory loss in human brain…..read more

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